Publication detail
Experimental model of human airways for flow, particle transport and deposition study
JEDELSKÝ, J. LÍZAL, F. JÍCHA, M. KRŠEK, P. ŠTĚTINA, J. KOŠNER, J.
Czech title
Experimentální model dýchacích cest člověka pro studium proudění, transportu a depozice částic
English title
Experimental model of human airways for flow, particle transport and deposition study
Type
abstract
Language
en
Original abstract
Better understanding of the transport, penetration and dispersion of particles as well as their deposition in the human lungs is needed to increase transport efficiency of therapeutic drugs. One of the approaches is an experimental investigation of flow in transparent airway model by optical methods. To enable optical measurement of aerosol transport with air as working fluid, we created realistic thin-walled transparent model of the airways. Aerosol is generated in desired size and concentration and the breathing cycle is simulated by pneumatic mechanism. Novel technique was developed for manufacturing of thin-walled lung model. As a generator of oscillating flow, a servo motor which drives piston through the cylinder is used. The servo motor is computer controlled and it allows generating any shape of motion with appropriate frequency and amplitude. Monodisperse aerosol particles of DEHS ranging from 1 to 10 um, used for deposition study and flow visualization in optical measurements are generated by condensation generator. Measurement of drop size and concentration is made by an aerosol monitor.
Czech abstract
Lepší pochopení proudění, transportu a depozice částic v lidských plících je nutné pro zvýšení účinnosti trasnportu léků. Pro optické metody měření byl vyroben novou metodu transparentní realistcký model dýchacího traktu. Experimenty porobíhají se vzduchem a aerosolem. Aerosol je generován kondenzačním generátorem v rozsahu 1-10 um, cyklické proudění vzduchu zajišťuje počítačově řízený pneumatický mechanismus.
English abstract
Better understanding of the transport, penetration and dispersion of particles as well as their deposition in the human lungs is needed to increase transport efficiency of therapeutic drugs. One of the approaches is an experimental investigation of flow in transparent airway model by optical methods. To enable optical measurement of aerosol transport with air as working fluid, we created realistic thin-walled transparent model of the airways. Aerosol is generated in desired size and concentration and the breathing cycle is simulated by pneumatic mechanism. Novel technique was developed for manufacturing of thin-walled lung model. As a generator of oscillating flow, a servo motor which drives piston through the cylinder is used. The servo motor is computer controlled and it allows generating any shape of motion with appropriate frequency and amplitude. Monodisperse aerosol particles of DEHS ranging from 1 to 10 um, used for deposition study and flow visualization in optical measurements are generated by condensation generator. Measurement of drop size and concentration is made by an aerosol monitor.
Keywords in Czech
Experimentální model, dýchací cesty, proudění, transport a depozice částic
Keywords in English
lung model, aerosol measurement, lung deposition, Laser Doppler anemometry
RIV year
2008
Released
25.08.2008
Publisher
Hellenic Associacion for Aerosol Research
Location
Thessaloniki, Greace
Book
Sborník z European aerosol conference. Thessaloniki, Greace. 2008
Edition number
1
Pages from–to
1–1
Pages count
1