Experimentální model dýchacích cest člověka pro studium proudění, transportu a depozice částic

Experimental model of human airways for flow, particle transport and deposition study

abstrakt

en

Better understanding of the transport, penetration and dispersion of particles as well as their deposition in the human lungs is needed to increase transport efficiency of therapeutic drugs. One of the approaches is an experimental investigation of flow in transparent airway model by optical methods. To enable optical measurement of aerosol transport with air as working fluid, we created realistic thin-walled transparent model of the airways. Aerosol is generated in desired size and concentration and the breathing cycle is simulated by pneumatic mechanism. Novel technique was developed for manufacturing of thin-walled lung model. As a generator of oscillating flow, a servo motor which drives piston through the cylinder is used. The servo motor is computer controlled and it allows generating any shape of motion with appropriate frequency and amplitude. Monodisperse aerosol particles of DEHS ranging from 1 to 10 um, used for deposition study and flow visualization in optical measurements are generated by condensation generator. Measurement of drop size and concentration is made by an aerosol monitor.

Lepší pochopení proudění, transportu a depozice částic v lidských plících je nutné pro zvýšení účinnosti trasnportu léků. Pro optické metody měření byl vyroben novou metodu transparentní realistcký model dýchacího traktu. Experimenty porobíhají se vzduchem a aerosolem. Aerosol je generován kondenzačním generátorem v rozsahu 1-10 um, cyklické proudění vzduchu zajišťuje počítačově řízený pneumatický mechanismus.

Better understanding of the transport, penetration and dispersion of particles as well as their deposition in the human lungs is needed to increase transport efficiency of therapeutic drugs. One of the approaches is an experimental investigation of flow in transparent airway model by optical methods. To enable optical measurement of aerosol transport with air as working fluid, we created realistic thin-walled transparent model of the airways. Aerosol is generated in desired size and concentration and the breathing cycle is simulated by pneumatic mechanism. Novel technique was developed for manufacturing of thin-walled lung model. As a generator of oscillating flow, a servo motor which drives piston through the cylinder is used. The servo motor is computer controlled and it allows generating any shape of motion with appropriate frequency and amplitude. Monodisperse aerosol particles of DEHS ranging from 1 to 10 um, used for deposition study and flow visualization in optical measurements are generated by condensation generator. Measurement of drop size and concentration is made by an aerosol monitor.

Experimentální model, dýchací cesty, proudění, transport a depozice částic

lung model, aerosol measurement, lung deposition, Laser Doppler anemometry

2008

25.08.2008

Hellenic Associacion for Aerosol Research

Thessaloniki, Greace

Sborník z European aerosol conference. Thessaloniki, Greace. 2008

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