Publication detail

Effect of modulation of ionic channel conductivities on restitution processes in cardiac cells (Computer modelling).

PÁSEK, M. ŠLICHTA, J.

English title

Effect of modulation of ionic channel conductivities on restitution processes in cardiac cells (Computer modelling).

Type

conference paper

Language

en

Original abstract

The restitution properties of cardiac action potential were shown to be important determinants of stability of reentrant arrhythmias. The restitution hypothesis states that steeply sloped restitution curves (relations between action potential duration and preceding diastolic interval) induce unstable wave propagation that results in wave break, the event that leads to fibrillation. In this contribution we try to explore the effect of modulation of membrane channel conductuvities on electrical restitution curves by means of computer modelling.

English abstract

The restitution properties of cardiac action potential were shown to be important determinants of stability of reentrant arrhythmias. The restitution hypothesis states that steeply sloped restitution curves (relations between action potential duration and preceding diastolic interval) induce unstable wave propagation that results in wave break, the event that leads to fibrillation. In this contribution we try to explore the effect of modulation of membrane channel conductuvities on electrical restitution curves by means of computer modelling.

Keywords in English

cardiac cell, electrical restitution

Released

01.01.2001

Publisher

Institute of Solid Mechanics, Faculty of Mechanical Engineer

Location

Třešť

ISBN

80-7204-207-6

Book

Mechatronics robotics and biomechanics

Pages count

2

BIBTEX


@inproceedings{BUT5883,
  author="Michal {Pásek} and Jiří {Šlichta},
  title="Effect of modulation of ionic channel conductivities on restitution processes in cardiac cells (Computer modelling).",
  booktitle="Mechatronics robotics and biomechanics",
  year="2001",
  month="January",
  publisher="Institute of Solid Mechanics, Faculty of Mechanical Engineer",
  address="Třešť",
  isbn="80-7204-207-6"
}