Tensegritní struktury a jejich použití v modelech cytoskeletu

TENSEGRITY STRUCTURES AND THEIR APPLICATION IN MODELS OF CYTOSKELETON

conference paper

en

Investigation of principles of mechanotransduction in living animal cells creates a basis for understanding processes in cardio-vascular system such as tissue remodelation, atherosclerotic changes, growth of aneurysms, etc. To be able to estimate the biochemical response of the cell or tissue on a mechanical load, we need to determinate the very quantity (or set of quantities) that is responsible for this response. As cell is a complex structure with numerous components, it cannot be expected that this quantity will be found on the base of homogeneous continuum models. Therefore more complex (structural) finite element models of the mechanical behaviour of cells are needed. A new more realistic model of cytoskeleton has been created. The model should be able to simulate various mechanical tests of isolated cells. In future various types of tests carried out with the same type of cells (vascular smooth muscle cells) should be simulated with the aim to identify constitutive parameters of the individual components of the model.

Článek vysvětluje pojem tensegritní struktury a na příkladech ukazuje pravidla pro jejich tvorbu. Na základě těchto pravidel pak je vytvořen nový model cytoskeletu živočišné buňky.

Investigation of principles of mechanotransduction in living animal cells creates a basis for understanding processes in cardio-vascular system such as tissue remodelation, atherosclerotic changes, growth of aneurysms, etc. To be able to estimate the biochemical response of the cell or tissue on a mechanical load, we need to determinate the very quantity (or set of quantities) that is responsible for this response. As cell is a complex structure with numerous components, it cannot be expected that this quantity will be found on the base of homogeneous continuum models. Therefore more complex (structural) finite element models of the mechanical behaviour of cells are needed. A new more realistic model of cytoskeleton has been created. The model should be able to simulate various mechanical tests of isolated cells. In future various types of tests carried out with the same type of cells (vascular smooth muscle cells) should be simulated with the aim to identify constitutive parameters of the individual components of the model.

Keywords: Tensegrity, cytoskeleton, mechanotransduction, finite element model

2006

13.11.2006

Brno University of Technology, Institute of Solid mechanics, Mechatronics and Biomechanics

Hrotovice

80-214-3232-2

Human Biomechanics 2006

Nezařazené články

68–69

8