Publication detail
Tensigrity Principle Based Computational Model of Cytoskeleton.
BANSOD, Y. BURŠA, J.
Czech title
Tensegrita Princip založený výpočtový model cytoskeletu
English title
Tensigrity Principle Based Computational Model of Cytoskeleton.
Type
conference paper
Language
en
Original abstract
The cytoskeleton plays a vital role in intracellular transmission of mechanical signals. The computational model of cytoskeleton based on tensegrity principle presented here has tension supporting cables representing microfilaments, compression supporting struts representing microtubules and springs in tension representing intermediate filaments. The nucleoskeleton and centrosome modelled as self-stabilised regular truncated tensegrity structures aimed to withstand high prestress. Integrins connecting cell with extracellular matrix are also considered to define cell behaviour in vivo. In this way, a more realistic computational model of cytoskeleton for different cell types could be designed for better understanding of respective cell motility and intracellular transmission of mechanical signals.
Czech abstract
Tento článek popisuje modelovací přístupy pro mikrostruktury částí živých buněk.
English abstract
The cytoskeleton plays a vital role in intracellular transmission of mechanical signals. The computational model of cytoskeleton based on tensegrity principle presented here has tension supporting cables representing microfilaments, compression supporting struts representing microtubules and springs in tension representing intermediate filaments. The nucleoskeleton and centrosome modelled as self-stabilised regular truncated tensegrity structures aimed to withstand high prestress. Integrins connecting cell with extracellular matrix are also considered to define cell behaviour in vivo. In this way, a more realistic computational model of cytoskeleton for different cell types could be designed for better understanding of respective cell motility and intracellular transmission of mechanical signals.
Keywords in Czech
buněčné mechanika, výpočtové modely, Tensegrita, cytoskelet
Keywords in English
Cell mechanics, computational models, Tensegrity, Cytoskeleton
RIV year
2014
Released
15.07.2014
Publisher
6th World Conference on Structural Control and Monitoring (6WCSCM).
Location
Barcelona, Spain
ISBN
978-84-942844-5-8
Book
6th World Conference on Structural Control and Monitoring (6WCSCM)
Pages from–to
3317–3326
Pages count
10
BIBTEX
@inproceedings{BUT116147,
author="Yogesh Deepak {Bansod} and Jiří {Burša},
title="Tensigrity Principle Based Computational Model of Cytoskeleton.",
booktitle="6th World Conference on Structural Control and Monitoring (6WCSCM)",
year="2014",
month="July",
pages="3317--3326",
publisher="6th World Conference on Structural Control and Monitoring (6WCSCM).",
address="Barcelona, Spain",
isbn="978-84-942844-5-8"
}