Publication detail
Application of Positron Emission Tomography to Aerosol Transport Research in a Model of Human Lungs
LÍZAL, F. JEDELSKÝ, J. ADAM, J. BĚLKA, M. JÍCHA, M.
Czech title
Aplikace pozitronové emisní tomografie na výzkum transportu aerosolu v modelu lidských plic
English title
Application of Positron Emission Tomography to Aerosol Transport Research in a Model of Human Lungs
Type
conference paper
Language
en
Original abstract
Positron Emission Tomography (PET) is a convenient method for measurement of aerosol deposition in complex models of lungs. It allows not only the evaluation of regional deposition characteristics but also precisely detects deposition hot spots. The method is based on a detection of a pair of annihilation photons moving in opposite directions as a result of positron – electron interaction after the positron emission decay of a suitable radioisotope. Liquid di(2-ethylhexyl) sebacate (DEHS) particles tagged with fluorine-18 as a radioactive tracer were generated by condensation monodisperse aerosol generator. Aerosol deposition was measured for three different inhalation flowrates and for two sizes of particles. Combination of PET with Computed Tomography (CT) in one device allowed precise localisation of particular segments of the model. The results proved correlation of deposition efficiency with Stokes number, which means that the main deposition mechanism is inertial impaction. As a next task the methodology for tagging the solid aerosol particles with radioactive tracer will be developed and deposition of porous and fiber aerosols will be measured.
Czech abstract
Pozitronová emisní tomografie (PET) je vhodná metoda pro měření depozice aerosolu ve složitých modelech plic. Umožňuje jak určení regionálních depozičních charakteristik, tak i lokalizaci depozičních ohnisek. Metoda je založena na detekci páru anihilačních fotonů, které se pohybují v opačných směrech jako výsledek interakce elektronu a pozitronu po emisi pozitronů z vhodného radioizotopu. Depozice aerosolu byla měřena pro tři režimy a dvě velikosti částic. Výsledky prokázaly korelaci mezi depoziční účinností a Stokesovým číslem, což znamená, že v měřených režimech je dominantním depozičním mechanismem setrvačný impakt.
English abstract
Positron Emission Tomography (PET) is a convenient method for measurement of aerosol deposition in complex models of lungs. It allows not only the evaluation of regional deposition characteristics but also precisely detects deposition hot spots. The method is based on a detection of a pair of annihilation photons moving in opposite directions as a result of positron – electron interaction after the positron emission decay of a suitable radioisotope. Liquid di(2-ethylhexyl) sebacate (DEHS) particles tagged with fluorine-18 as a radioactive tracer were generated by condensation monodisperse aerosol generator. Aerosol deposition was measured for three different inhalation flowrates and for two sizes of particles. Combination of PET with Computed Tomography (CT) in one device allowed precise localisation of particular segments of the model. The results proved correlation of deposition efficiency with Stokes number, which means that the main deposition mechanism is inertial impaction. As a next task the methodology for tagging the solid aerosol particles with radioactive tracer will be developed and deposition of porous and fiber aerosols will be measured.
Keywords in Czech
transport aerosolu, depozice aerosolu, pozitronová emisní tomografie, model plic
Keywords in English
aerosol transport, aerosol deposition, positron emission tomography, human lung model
RIV year
2012
Released
09.04.2013
Publisher
EDP Sciences
Location
Francie
ISBN
978-80-7372-912-7
ISSN
2100-014X
Book
EPJ Web of Conferences
Volume
45
Number
1
Pages from–to
1–4
Pages count
4
BIBTEX
@inproceedings{BUT95329,
author="František {Lízal} and Jan {Jedelský} and Jan {Adam} and Miloslav {Bělka} and Miroslav {Jícha},
title="Application of Positron Emission Tomography to Aerosol Transport Research in a Model of Human Lungs",
booktitle="EPJ Web of Conferences",
year="2013",
volume="45",
number="1",
month="April",
pages="1--4",
publisher="EDP Sciences",
address="Francie",
isbn="978-80-7372-912-7",
issn="2100-014X"
}