Publication detail

The flow of inhaled fibres in a model of the first bifurcation in human airways under transient conditions

LÍZAL, F. CABALKA, M. MALÝ, M. BĚLKA, M. MIŠÍK, O. JEDELSKÝ, J.

English title

The flow of inhaled fibres in a model of the first bifurcation in human airways under transient conditions

Type

article in a collection out of WoS and Scopus

Language

en

Original abstract

Inhaled fibres are known to induce various adverse health effects due to their ability to penetrate deep into the lower regions of the human lungs. This behaviour, however, could potentially be used for delivery of therapeutic drugs to alveoli. Such conversion of originally adverse behaviour to a beneficial and health-improving solution would be not only witty but also potentially commercially attractive. The reason why this potential has not been exploited so far grounds, besides other factors, also in the fact that our current mathematical or computational models are unable to precisely predict the delivered dose for a specific patient. Experimental data on the flow, orientation and “flips” of fibres are needed to improve the current mathematical models. This contribution presents the experimental setup and statistically evaluated data on the behaviour of rigid micrometre-sized fibres in the replica of the first bifurcation in human airways under transient conditions.

English abstract

Inhaled fibres are known to induce various adverse health effects due to their ability to penetrate deep into the lower regions of the human lungs. This behaviour, however, could potentially be used for delivery of therapeutic drugs to alveoli. Such conversion of originally adverse behaviour to a beneficial and health-improving solution would be not only witty but also potentially commercially attractive. The reason why this potential has not been exploited so far grounds, besides other factors, also in the fact that our current mathematical or computational models are unable to precisely predict the delivered dose for a specific patient. Experimental data on the flow, orientation and “flips” of fibres are needed to improve the current mathematical models. This contribution presents the experimental setup and statistically evaluated data on the behaviour of rigid micrometre-sized fibres in the replica of the first bifurcation in human airways under transient conditions.

Keywords in English

fibres; aerosol; inhaled; human airways

Released

03.10.2022

Publisher

Česká aerosolová společnost

Location

Kutná Hora

ISBN

978-80-908653-0-3

Book

PROCEEDINGS OF 21st ANNUAL CONFERENCE OF THE CZECH AEROSOL SOCIETY

Pages from–to

103–104

Pages count

2

BIBTEX


@inproceedings{BUT180551,
  author="František {Lízal} and Matouš {Cabalka} and Milan {Malý} and Miloslav {Bělka} and Ondrej {Mišík} and Jan {Jedelský},
  title="The flow of inhaled fibres in a model of the first bifurcation in human airways under transient conditions ",
  booktitle="PROCEEDINGS OF 21st ANNUAL CONFERENCE OF THE CZECH AEROSOL SOCIETY",
  year="2022",
  month="October",
  pages="103--104",
  publisher="Česká aerosolová společnost",
  address="Kutná Hora",
  isbn="978-80-908653-0-3"
}