Publication detail
IMPACT OF FORMALDEHYDE ON MECHANICAL PROPERTIES OF ATHEROSCLEROTIC CAROTID ARTERIES
HRUBANOVÁ, A. LISICKÝ, O. BARTOŇOVÁ, P. STAFFA, R. HERMANOVÁ, M. VLACHOVSKÝ, R. BURŠA, J.
English title
IMPACT OF FORMALDEHYDE ON MECHANICAL PROPERTIES OF ATHEROSCLEROTIC CAROTID ARTERIES
Type
conference paper
Language
en
Original abstract
Atherosclerosis is a life threatening cardiovascular disease causing lipoprotein accumulation within intima layer of artery wall and thus its thickening. Later stages are characterized by plaque formation with a lipid core separated from lumen by fibrous cap. In case of carotid arteries (CA), rupture of the plaque often results in a stroke. Detailed understanding of mechanical properties of atherosclerotic arteries and their components is essential for improvement of computer models used for prediction of plaque rupture. Samples of atherosclerotic CA from carotid endarterectomy were kept either in saline solution or in formaldehyde solution and then underwent uniaxial tensile testing in two directions. Statistical analysis of the obtained stress-strain responses shows that formaldehyde treatment of the tissue increases significantly the mean stiffness and reduces the dispersion.
English abstract
Atherosclerosis is a life threatening cardiovascular disease causing lipoprotein accumulation within intima layer of artery wall and thus its thickening. Later stages are characterized by plaque formation with a lipid core separated from lumen by fibrous cap. In case of carotid arteries (CA), rupture of the plaque often results in a stroke. Detailed understanding of mechanical properties of atherosclerotic arteries and their components is essential for improvement of computer models used for prediction of plaque rupture. Samples of atherosclerotic CA from carotid endarterectomy were kept either in saline solution or in formaldehyde solution and then underwent uniaxial tensile testing in two directions. Statistical analysis of the obtained stress-strain responses shows that formaldehyde treatment of the tissue increases significantly the mean stiffness and reduces the dispersion.
Keywords in English
Atherosclerotic plaque, Carotid artery, Mechanical properties, Uniaxial tensile test
Released
24.11.2020
ISBN
978-80-214-5896-3
Book
ENGINEERING MECHANICS 2020
Pages from–to
210–213
Pages count
4
BIBTEX
@inproceedings{BUT166394,
author="Anna {Hrubanová} and Ondřej {Lisický} and Petra {Bartoňová} and Robert {Staffa} and Markéta {Hermanová} and Robert {Vlachovský} and Jiří {Burša},
title="IMPACT OF FORMALDEHYDE ON MECHANICAL PROPERTIES OF ATHEROSCLEROTIC CAROTID ARTERIES",
booktitle="ENGINEERING MECHANICS 2020",
year="2020",
month="November",
pages="210--213",
isbn="978-80-214-5896-3"
}