Experimental methods applicable in research of flow and aerosol deposition in human airways and their replicas

lecture

en

Computer simulations will undoubtedly bring deeper insight into the mechanisms important for the inhaled aerosol therapy. However, validation of computational codes and their results is still an utterly necessary step on the way to trustworthy numerical modelling. This talk introduces the available methods for the measurement of respiratory airflow and deposition of inhaled particles, both in vivo and in replicas of airways. Four categories of methods will be introduced: 1) point-wise and planar methods for velocimetry in the airways, 2) classic methods for the measurement of the regional distribution of inhaled particles, 3) standard medical imaging methods applicable to the measurement of the regional aerosol distribution and 4) emerging and nonconventional methods. Each of the presented experimental methods has its limitations and advantages, these will be discussed and evaluated.

Computer simulations will undoubtedly bring deeper insight into the mechanisms important for the inhaled aerosol therapy. However, validation of computational codes and their results is still an utterly necessary step on the way to trustworthy numerical modelling. This talk introduces the available methods for the measurement of respiratory airflow and deposition of inhaled particles, both in vivo and in replicas of airways. Four categories of methods will be introduced: 1) point-wise and planar methods for velocimetry in the airways, 2) classic methods for the measurement of the regional distribution of inhaled particles, 3) standard medical imaging methods applicable to the measurement of the regional aerosol distribution and 4) emerging and nonconventional methods. Each of the presented experimental methods has its limitations and advantages, these will be discussed and evaluated.

aerosol, flow, human airways, human lungs, model

01.10.2019

The SimInhale International Conference: International Conference on Current Challenges and Future Opportunities for Inhalation Therapies.

Athens, Greece

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