Publication detail
MICRO-FLUIDIC SYSTEM WITH GROOVED POLE PIECES OF MAGNETIC CIRCUIT
MACHÁČEK, O. KUBÍK, M. ROUPEC, J. STRECKER, Z. MAZŮREK, I.
English title
MICRO-FLUIDIC SYSTEM WITH GROOVED POLE PIECES OF MAGNETIC CIRCUIT
Type
conference paper
Language
en
Original abstract
Micro-fluidic systems are used in approximately 30 years for detect or separate biological molecules which are contain in a biological medium (blood, serum, etc.). The technique of separation is based on magnetic force acting on the magnetic particles which are added to the medium. One way to increase separation efficiency is to optimize the magnetic circuit. Two versions of magnetic circuit for the micro-fluidic system are designed, tested and compared in this study. The first of them has solid pole pieces (without grooves), the second one is provided with grooves which are oriented perpendicular to the direction of a fluid flow through the system. A suitable geometry of the grooves was chosen using a FEM model which is verified by measurement. Hypothesis that the grooved pole pieces ensure higher amount of captured particles in the system in comparison with the case of solid pole pieces was confirmed. But, the comparison of the captured particles amount was made just visually. Therefore, the amount of particles which are washout during a flow test should be evaluated by more quantifiable method in future study, for example using Beer-Lambert law.
English abstract
Micro-fluidic systems are used in approximately 30 years for detect or separate biological molecules which are contain in a biological medium (blood, serum, etc.). The technique of separation is based on magnetic force acting on the magnetic particles which are added to the medium. One way to increase separation efficiency is to optimize the magnetic circuit. Two versions of magnetic circuit for the micro-fluidic system are designed, tested and compared in this study. The first of them has solid pole pieces (without grooves), the second one is provided with grooves which are oriented perpendicular to the direction of a fluid flow through the system. A suitable geometry of the grooves was chosen using a FEM model which is verified by measurement. Hypothesis that the grooved pole pieces ensure higher amount of captured particles in the system in comparison with the case of solid pole pieces was confirmed. But, the comparison of the captured particles amount was made just visually. Therefore, the amount of particles which are washout during a flow test should be evaluated by more quantifiable method in future study, for example using Beer-Lambert law.
Keywords in English
Micro-fluidic system, immunoassay, magnetic circuit, grooved pole pieces
Released
14.05.2018
Publisher
Institute of Theoretical and Applied Mechanics of the Czech Academy of Sciences
Location
Prague
ISBN
978-80-86246-88-8
ISSN
1805-8256
Book
ENGINEERING MECHANICS 2018
Volume
24
Number
1
Pages from–to
521–524
Pages count
4
BIBTEX
@inproceedings{BUT151987,
author="Ondřej {Macháček} and Michal {Kubík} and Jakub {Roupec} and Zbyněk {Strecker} and Ivan {Mazůrek},
title="MICRO-FLUIDIC SYSTEM WITH GROOVED POLE PIECES OF MAGNETIC CIRCUIT",
booktitle="ENGINEERING MECHANICS 2018",
year="2018",
volume="24",
number="1",
month="May",
pages="521--524",
publisher="Institute of Theoretical and Applied Mechanics of the Czech Academy of Sciences",
address="Prague",
isbn="978-80-86246-88-8",
issn="1805-8256"
}