Výpočtový model cytoskeletu , založený na principu Tensegrity

Computational Model of Cytoskeleton Based on Tensegrity Principle

abstract

en

Ingber proposed tensegrity model for cytoskeleton which viewed actin filaments as tension supporting cables and microtubules as compression-supporting struts. In present model the tensed membrane skeleton is constructed out of polyhedron and consists of cross-linked microfilaments only. Microtubules, modelled as discrete compression members, emerge from centrosome, have unequal lengths and form a star shape. Intermediate filaments are modelled as springs in tension, tangential to nucleoskeleton and spread throughout intracellular region. In this way various more realistic computational cellular tensegrity models could be designed for better understanding of cellular mechanics.

Příspěvek pojednává o modely buněčných mechaniky na základě kontinua přístupy.

Ingber proposed tensegrity model for cytoskeleton which viewed actin filaments as tension supporting cables and microtubules as compression-supporting struts. In present model the tensed membrane skeleton is constructed out of polyhedron and consists of cross-linked microfilaments only. Microtubules, modelled as discrete compression members, emerge from centrosome, have unequal lengths and form a star shape. Intermediate filaments are modelled as springs in tension, tangential to nucleoskeleton and spread throughout intracellular region. In this way various more realistic computational cellular tensegrity models could be designed for better understanding of cellular mechanics.

buněčné mechanika, výpočtové modely, Tensegrita

Cell mechanics, computational models, Tensegrity

21.05.2014

XXII Cytoskeletal Club, Veterinary Research Institute, Masaryk University.

Vranovska Ves, Czech Republic.