Detail publikace
Tensegritní konečnoprvkové modely mechanických zkoušek izolovaných buněk
BURŠA, J. HOLATA, J. LEBIŠ, R.
Český název
Tensegritní konečnoprvkové modely mechanických zkoušek izolovaných buněk
Anglický název
Tensegrity finite element models of mechanical tests of individual cells
Typ
článek v časopise - ostatní, Jost
Jazyk
en
Originální abstrakt
A three-dimensional finite element model of a vascular smooth muscle cell is based on models published recently; it comprehends elements representing cell membrane, cytoplasm and nucleus, and a complex tensegrity structure representing the cytoskeleton. In contrast to previous models of eucaryotic cells, this tensegrity structure consists of several parts. Its external and internal parts number 30 struts, 60 cables each, and their nodes are interconnected by 30 radial members; these parts represent cortical, nuclear and deep cytoskeletons, respectively. This arrangement enables us to simulate load transmission from the extracellular space to the nucleus or centrosome via membrane receptors (focal adhesions); the ability of the model was tested by simulation of some mechanical tests with isolated vascular smooth muscle cells. Although material properties of components defined on the basis of the mechanical tests are ambiguous, modelling of different types of tests has shown the ability of the model to simulate substantial global features of cell behaviour, e.g. action at a distance effect or the global load-deformation response of the cell under various types of loading. Based on computational simulations, the authors offer a hypothesis explaining the scatter of experimental results of indentation tests.
Český abstrakt
Je představen 3D konečnoprvkový model hladké svalové buňky, v němž je cytoskelet modelován pomocí tensegritní struktury s 210 prvky. Tento model je využit k simulaci zkoušky tahem a zkoušky průniku, materiálové parametry jsou nastaveny na základě výsledků experimentů.
Anglický abstrakt
A three-dimensional finite element model of a vascular smooth muscle cell is based on models published recently; it comprehends elements representing cell membrane, cytoplasm and nucleus, and a complex tensegrity structure representing the cytoskeleton. In contrast to previous models of eucaryotic cells, this tensegrity structure consists of several parts. Its external and internal parts number 30 struts, 60 cables each, and their nodes are interconnected by 30 radial members; these parts represent cortical, nuclear and deep cytoskeletons, respectively. This arrangement enables us to simulate load transmission from the extracellular space to the nucleus or centrosome via membrane receptors (focal adhesions); the ability of the model was tested by simulation of some mechanical tests with isolated vascular smooth muscle cells. Although material properties of components defined on the basis of the mechanical tests are ambiguous, modelling of different types of tests has shown the ability of the model to simulate substantial global features of cell behaviour, e.g. action at a distance effect or the global load-deformation response of the cell under various types of loading. Based on computational simulations, the authors offer a hypothesis explaining the scatter of experimental results of indentation tests.
Klíčová slova česky
biomechanika buňky; tensegritní struktura; cytoskeleton; výpočtový model
Klíčová slova anglicky
Cell biomechanics; Tensegrity structure; Cytoskeleton; Computational model
Rok RIV
2012
Vydáno
16.04.2012
Nakladatel
Elsevier Science B.V.
Místo
Amsterdam
ISSN
0928-7329
Ročník
20
Číslo
2
Strany od–do
135–150
Počet stran
16
BIBTEX
@article{BUT88700,
author="Jiří {Burša} and Jakub {Holata} and Radek {Lebiš},
title="Tensegrity finite element models of mechanical tests of individual cells",
year="2012",
volume="20",
number="2",
month="April",
pages="135--150",
publisher="Elsevier Science B.V.",
address="Amsterdam",
issn="0928-7329"
}