Detail publikace
Transport aerosolu v modelu lidských plic
LÍZAL, F. JEDELSKÝ, J. LIPPAY, J. HALASOVÁ, T. MRAVEC, F. JÍCHA, M.
Český název
Transport aerosolu v modelu lidských plic
Anglický název
Aerosol Transport in a Model of Human Lungs
Typ
článek ve sborníku ve WoS nebo Scopus
Jazyk
en
Originální abstrakt
Complex flow structures emerging in human lungs significantly affect deposition of inhaled particles. Therefore flow measurements alongside with deposition measurements have to be performed on the same model geometry. Amount of deposited aerosol particles in different regions of lungs could be measured by several methods. Gamma detection of radioactive tagged particles is subjected to strict regulations and is expensive; gravimetry and fluorometry are thus preferred in current studies. Novel methodology for fluorometric measurement of aerosol transport in models of human lungs was developed. Some previously published experiments were performed using condensation of di(2-ethylhexyl) sebacate (DEHS) vapours on fluorescein nuclei. Their authors assumed that fluorescein is necessary for generation of fluorescent particles and they neglected possible fluorescence of DEHS itself. Our analysis of DEHS characteristics indicated that DEHS fluorescence could be detected apart in sufficient rate to evaluate aerosol deposition. Consequently experiments in standard setup of condensation monodisperse aerosol generator with sodium chloride nuclei instead of fluorescein were performed. Results demonstrating applicability and limitations of DEHS particles for fluorometric deposition measurements are presented and discussed.
Český abstrakt
Složité struktury proudění, které se vyvíjejí v lidských dýchacích cestách, ovlivňují depozici vdechovaných částic. Článek se zabývá použitím fluorometrické metody pro měření depozice částic aerosolu, konkrétně možností využití fluorescence di-2-ethyl hexyl sebacatu (DEHS) pro fluorescenční měření. Jsou prezentovány experimenty potvrzující fluorescenční vlastnosti DEHS a limity jeho použití.
Anglický abstrakt
Complex flow structures emerging in human lungs significantly affect deposition of inhaled particles. Therefore flow measurements alongside with deposition measurements have to be performed on the same model geometry. Amount of deposited aerosol particles in different regions of lungs could be measured by several methods. Gamma detection of radioactive tagged particles is subjected to strict regulations and is expensive; gravimetry and fluorometry are thus preferred in current studies. Novel methodology for fluorometric measurement of aerosol transport in models of human lungs was developed. Some previously published experiments were performed using condensation of di(2-ethylhexyl) sebacate (DEHS) vapours on fluorescein nuclei. Their authors assumed that fluorescein is necessary for generation of fluorescent particles and they neglected possible fluorescence of DEHS itself. Our analysis of DEHS characteristics indicated that DEHS fluorescence could be detected apart in sufficient rate to evaluate aerosol deposition. Consequently experiments in standard setup of condensation monodisperse aerosol generator with sodium chloride nuclei instead of fluorescein were performed. Results demonstrating applicability and limitations of DEHS particles for fluorometric deposition measurements are presented and discussed.
Klíčová slova česky
depozice aerosolu, DEHS, model plic
Klíčová slova anglicky
aerosol deposition, DEHS, lung model
Rok RIV
2011
Vydáno
22.11.2011
Nakladatel
Technical University of Liberec
Místo
Liberec, Czech Republic
ISBN
978-80-7372-784-0
Kniha
Experimental Fluid Mechanics 2011 Conference Proceedings Volume 1
Strany od–do
281–288
Počet stran
9
BIBTEX
@inproceedings{BUT92795,
author="František {Lízal} and Jan {Jedelský} and Josef {Lippay} and Tereza {Venerová} and Filip {Mravec} and Miroslav {Jícha},
title="Aerosol Transport in a Model of Human Lungs",
booktitle="Experimental Fluid Mechanics 2011 Conference Proceedings Volume 1",
year="2011",
month="November",
pages="281--288",
publisher="Technical University of Liberec",
address="Liberec, Czech Republic",
isbn="978-80-7372-784-0"
}