EXPERIMENTÁLNÍ STUDIUM DEPOZICE AEROSOLU V REALISTICKÉM MODELU PLIC

EXPERIMENTAL STUDY OF AEROSOL DEPOSITION IN A REALISTIC LUNG MODEL

článek v časopise - ostatní, Jost

en

The inhalation route for administration of medicaments is becoming more and more popular in recent years. The reason is non-invasiveness of the method and instantaneous absorption of drugs to the blood circulation. It is necessary to deliver exact amount of drug to the specific segment because of occurrence of diverse diseases in different segments of lungs. The aim of our work is to contribute to better understanding of transport and deposition of aerosolized drugs in lungs and hence to more effective treatment of respiratory diseases due to the targeted drug delivery. We provided measurements of aerosol deposition in segmented realistic model of lungs without a mouth cavity. Monodisperse particles marked with fluorescein were supplied to the model. The model was then disassembled to segments and each segment was rinsed with isopropanol, whereby fluorescent samples were created. Each sample was analysed by fluorometer and an amount of aerosol deposited in the segment was calculated. Experiences obtained by this study were used for creation of a new model with the mouth cavity. This model will be used for future studies with porous and fiber aerosols.

Inhalační cesta k podání léčiv je v posledních letech stále populárnější. Důvodem je neinvazivnost metody a okamžité vstřebávání léků do krevního oběhu. často je nutné dodat přesné množství léku do konkrétní oblasti plic z důvodu výskytu různých chorob v různých segmentech plic. Cílem naší práce je přispět k lepšímu pochopení transportu a depozice aerosolu v plicích a tím i k účinnější léčbě respiračních onemocnění. Provedli jsme měření depozice aerosolu v segmentovém realistickém model plic bez ústní dutiny. Monodisperzní částice označené fluoresceinem byly dodávány do modelu. Model byl pak rozebrán na segmenty a každý segment byl vypláchnut isopropanolem, čímž byly vytvořeny fluorescenční vzorky. Každý vzorek byl analyzován fluorometrem a množství aerosolu usazeného v segmentu tak bylo přesně určeno. Zkušenosti získané při této studii byly použity pro vytvoření nového modelu s ústní dutinou. Tento model bude použit pro budoucí studium s porézními a vláknovými aerosoly.

The inhalation route for administration of medicaments is becoming more and more popular in recent years. The reason is non-invasiveness of the method and instantaneous absorption of drugs to the blood circulation. It is necessary to deliver exact amount of drug to the specific segment because of occurrence of diverse diseases in different segments of lungs. The aim of our work is to contribute to better understanding of transport and deposition of aerosolized drugs in lungs and hence to more effective treatment of respiratory diseases due to the targeted drug delivery. We provided measurements of aerosol deposition in segmented realistic model of lungs without a mouth cavity. Monodisperse particles marked with fluorescein were supplied to the model. The model was then disassembled to segments and each segment was rinsed with isopropanol, whereby fluorescent samples were created. Each sample was analysed by fluorometer and an amount of aerosol deposited in the segment was calculated. Experiences obtained by this study were used for creation of a new model with the mouth cavity. This model will be used for future studies with porous and fiber aerosols.

realistický model plic, model plic, depozice v plicích, depozice aerosolu, aerosol

realistic lung model, lung model, lung deposition, aerosol deposition, aerosol

2011

01.03.2011

VŠB - Technická univerzita Ostrava

Ostrava

1210-0471

LVI

3/2010

109–114

6