Výpočtové modelováníé chování měkkých biologických tkání

COMPUTATIONAL MODELLING OF BEHAVIOUR OF SOFT BIOLOGICAL TISSUES

článek ve sborníku ve WoS nebo Scopus

en

Abstract: The paper deals with computational modelling of mechanical behaviour of soft tissues in arterial wall. Three computational models are presented. Model No. 1 models abdominal aortic aneurysms (AAA) at the level of a multilayer aortic wall structure with hyperelastic isotropic material properties of the individual layers. The extreme principal stress in the AAA is evaluated and compared with the stress in an intact aorta. The ratio of these stresses should be used in the evaluation of AAA rupture risk. Model No. 2 models an individual smooth muscle cell (SMC) at the level of a homogeneous hyperelastic isotropic continuum. Parameters of the 5-parameter-Mooney-Rivlin constitutive model are identified from the tension test of the SMC. Model No.3 models tension and indentation tests of SMCs with taking the cell structure into account, with cytoskeleton represented by a simple tensegrity structure.

The paper deals with computational modelling of mechanical behaviour of soft tissues in arterial wall. Three computational models are presented. Model No. 1 models abdominal aortic aneurysms (AAA) at the level of a multilayer aortic wall structure with hyperelastic isotropic material properties of the individual layers. The extreme principal stress in the AAA is evaluated and compared with the stress in an intact aorta. The ratio of these stresses should be used in the evaluation of AAA rupture risk. Model No. 2 models an individual smooth muscle cell (SMC) at the level of a homogeneous hyperelastic isotropic continuum. Parameters of the 5-parameter-Mooney-Rivlin constitutive model are identified from the tension test of the SMC. Model No.3 models tension and indentation tests of SMCs with taking the cell structure into account, with cytoskeleton represented by a simple tensegrity structure.

Abstract: The paper deals with computational modelling of mechanical behaviour of soft tissues in arterial wall. Three computational models are presented. Model No. 1 models abdominal aortic aneurysms (AAA) at the level of a multilayer aortic wall structure with hyperelastic isotropic material properties of the individual layers. The extreme principal stress in the AAA is evaluated and compared with the stress in an intact aorta. The ratio of these stresses should be used in the evaluation of AAA rupture risk. Model No. 2 models an individual smooth muscle cell (SMC) at the level of a homogeneous hyperelastic isotropic continuum. Parameters of the 5-parameter-Mooney-Rivlin constitutive model are identified from the tension test of the SMC. Model No.3 models tension and indentation tests of SMCs with taking the cell structure into account, with cytoskeleton represented by a simple tensegrity structure.

Výpočtové modelování, hladká svalová buňka

Computational modelling, smooth muscle cell

2005

20.11.2005

Prague

1727-1983

IFMBE Proceedings

IFMBE Proceedings

2005

11

6