Detail publikace

Influence of inhalation flow rate on the particle size of liposomal carrier aerosol generated by the medical nebulizer

MIŠÍK, O. MALÝ, M. CEJPEK, O. SZABOVÁ, J. LÍZAL, F.

Anglický název

Influence of inhalation flow rate on the particle size of liposomal carrier aerosol generated by the medical nebulizer

Typ

článek ve sborníku mimo WoS a Scopus

Jazyk

en

Originální abstrakt

Abstract. Nebulizers are medical devices for inhalation treatment that create an aerosol from liquid drug formulation. The efficacy of the treatment is dependent on the particle size distribution (PSD) of generated aerosol. PSD can be influenced by the inhalation flow rate as well. Within the here-presented study PSD of aerosol generated by nebulizer Pari LC Sprint Star was measured by Phase Doppler Anemometry for inhalation flowrate of 8; 12; 20 and 40 l/min. The nebulized solution consisted of a liposomal system (20 %) from dipalmitoylfosfatidylcholine (DPPC), phosphatidic acid (PA) and cholesterol (Chol), and MiliQ – ultrapure water (80 %). Slight dependence of PSD on inhalation flow rate was identified. With the increasing flow rate, the particle size of generated aerosol is decreasing. However, the change of Dv50 with the measured flow rates was smaller than 1 μm. According to the results, the change in particle size induced by flow rate will not have a significant impact on drug delivery.

Anglický abstrakt

Abstract. Nebulizers are medical devices for inhalation treatment that create an aerosol from liquid drug formulation. The efficacy of the treatment is dependent on the particle size distribution (PSD) of generated aerosol. PSD can be influenced by the inhalation flow rate as well. Within the here-presented study PSD of aerosol generated by nebulizer Pari LC Sprint Star was measured by Phase Doppler Anemometry for inhalation flowrate of 8; 12; 20 and 40 l/min. The nebulized solution consisted of a liposomal system (20 %) from dipalmitoylfosfatidylcholine (DPPC), phosphatidic acid (PA) and cholesterol (Chol), and MiliQ – ultrapure water (80 %). Slight dependence of PSD on inhalation flow rate was identified. With the increasing flow rate, the particle size of generated aerosol is decreasing. However, the change of Dv50 with the measured flow rates was smaller than 1 μm. According to the results, the change in particle size induced by flow rate will not have a significant impact on drug delivery.

Klíčová slova anglicky

Aerosol, particle size, nebulizuer, flow rate, liposom

Vydáno

29.11.2022

Místo

Dvůr Králové nad Labem

Počet stran

4

BIBTEX


@inproceedings{BUT180626,
  author="Ondrej {Mišík} and Milan {Malý} and Ondřej {Cejpek} and Jana {Szabová} and František {Lízal},
  title="Influence of inhalation flow rate on the particle size of liposomal carrier aerosol generated by the medical nebulizer",
  year="2022",
  month="November",
  address="Dvůr Králové nad Labem"
}