Detail publikace
Tracing dsDNA Virus–Host Coevolution through Correlation of Their G-Quadruplex-Forming Sequences
BOHÁLOVÁ, N. CANTARA, A. BARTAS, M. KAURA, P. ŠŤASTNÝ, J. PEČINKA, P. FOJTA, M. BRÁZDA, V.
Anglický název
Tracing dsDNA Virus–Host Coevolution through Correlation of Their G-Quadruplex-Forming Sequences
Typ
článek v časopise ve Web of Science, Jimp
Jazyk
en
Originální abstrakt
The importance of gene expression regulation in viruses based upon G-quadruplex may point to its potential utilization in therapeutic targeting. Here, we present analyses as to the occurrence of putative G-quadruplex-forming sequences (PQS) in all reference viral dsDNA genomes and evaluate their dependence on PQS occurrence in host organisms using the G4Hunter tool. PQS frequencies differ across host taxa without regard to GC content. The overlay of PQS with annotated regions reveals the localization of PQS in specific regions. While abundance in some, such as repeat regions, is shared by all groups, others are unique. There is abundance within introns of Eukaryota-infecting viruses, but depletion of PQS in introns of bacteria-infecting viruses. We reveal a significant positive correlation between PQS frequencies in dsDNA viruses and corresponding hosts from archaea, bacteria, and eukaryotes. A strong relationship between PQS in a virus and its host indicates their close coevolution and evolutionarily reciprocal mimicking of genome organization.
Anglický abstrakt
The importance of gene expression regulation in viruses based upon G-quadruplex may point to its potential utilization in therapeutic targeting. Here, we present analyses as to the occurrence of putative G-quadruplex-forming sequences (PQS) in all reference viral dsDNA genomes and evaluate their dependence on PQS occurrence in host organisms using the G4Hunter tool. PQS frequencies differ across host taxa without regard to GC content. The overlay of PQS with annotated regions reveals the localization of PQS in specific regions. While abundance in some, such as repeat regions, is shared by all groups, others are unique. There is abundance within introns of Eukaryota-infecting viruses, but depletion of PQS in introns of bacteria-infecting viruses. We reveal a significant positive correlation between PQS frequencies in dsDNA viruses and corresponding hosts from archaea, bacteria, and eukaryotes. A strong relationship between PQS in a virus and its host indicates their close coevolution and evolutionarily reciprocal mimicking of genome organization.
Klíčová slova anglicky
Bioinformatics; Coevolution; DsDNA; G-quadruplex; G4Hunter; Host; Virus
Vydáno
01.04.2021
Nakladatel
MDPI
ISSN
1422-0067
Ročník
22
Číslo
7
Strany od–do
1–12
Počet stran
12
BIBTEX
@article{BUT171724,
author="Natália {Bohálová} and Alessio {Cantara} and Martin {Bartas} and Patrik {Kaura} and Jiří {Šťastný} and Petr {Pečinka} and Miroslav {Fojta} and Václav {Brázda},
title="Tracing dsDNA Virus–Host Coevolution through Correlation of Their G-Quadruplex-Forming Sequences",
year="2021",
volume="22",
number="7",
month="April",
pages="1--12",
publisher="MDPI",
issn="1422-0067"
}