Detail publikace
A new insight into more effective viscosupplementation based on the synergy of hyaluronic acid and phospholipids for cartilage friction reduction
HILŠER, P. SUCHÁNKOVÁ, A. MENDOVÁ, K. FILIPIČ, K.E. DANIEL, M. VRBKA, M.
Anglický název
A new insight into more effective viscosupplementation based on the synergy of hyaluronic acid and phospholipids for cartilage friction reduction
Typ
článek v časopise ve Scopus, Jsc
Jazyk
en
Originální abstrakt
Osteoarthritis is a joint disease characterized by progressive damage to the cartilage. For a long time, viscosupplements have been based on hyaluronic acid (HA), which is known to relieve the pain of osteoarthritic patients. Recently, however, it has been hypothesized that phospholipids and HA may be collectively responsible for the extremely low friction observed in joint models (mica tape), suggesting that such a combination might lead to more effective viscosupplements. Using a pin-on-plate tribometer, we have tested this hypothesis by analyzing the coefficient of friction of conventional HA viscosupplements compared to the new viscosupplement formula of phospholipids and HA. Our findings show that phospholipids and HA do indeed lead to the lowest friction in the joints at both cartilage-mica tape and cartilage-glass interfaces (joint models). Furthermore, these results also hold true when both viscosupplements are mixed with synovial fluid simulating the real conditions after viscosupplement injection into joints. Therefore, we have validated the synergic effect of phospholipids and HA on lowering the cartilage friction and we further hypothesized that this effect is due to hydration lubrication. We believe these findings might contribute to development of new viscosupplement which would significantly improve the lives of person suffering from osteoarthrosis.
Anglický abstrakt
Osteoarthritis is a joint disease characterized by progressive damage to the cartilage. For a long time, viscosupplements have been based on hyaluronic acid (HA), which is known to relieve the pain of osteoarthritic patients. Recently, however, it has been hypothesized that phospholipids and HA may be collectively responsible for the extremely low friction observed in joint models (mica tape), suggesting that such a combination might lead to more effective viscosupplements. Using a pin-on-plate tribometer, we have tested this hypothesis by analyzing the coefficient of friction of conventional HA viscosupplements compared to the new viscosupplement formula of phospholipids and HA. Our findings show that phospholipids and HA do indeed lead to the lowest friction in the joints at both cartilage-mica tape and cartilage-glass interfaces (joint models). Furthermore, these results also hold true when both viscosupplements are mixed with synovial fluid simulating the real conditions after viscosupplement injection into joints. Therefore, we have validated the synergic effect of phospholipids and HA on lowering the cartilage friction and we further hypothesized that this effect is due to hydration lubrication. We believe these findings might contribute to development of new viscosupplement which would significantly improve the lives of person suffering from osteoarthrosis.
Klíčová slova anglicky
Articular cartilage; Viscosupplement; Hyaluronic acid; Phospholipids; Mica; Hydration lubrication; Friction
Vydáno
06.02.2021
Nakladatel
Elsevier Ltd
Místo
Radarweg 29, 1043 NX Amsterdam, The Netherlands
ISSN
2352-5738
Ročník
25
Číslo
1
Strany od–do
100166–100166
Počet stran
11
BIBTEX
@article{BUT169575,
author="Pavel {Hilšer} and Martin {Vrbka},
title="A new insight into more effective viscosupplementation based on the synergy of hyaluronic acid and phospholipids for cartilage friction reduction",
year="2021",
volume="25",
number="1",
month="February",
pages="100166--100166",
publisher="Elsevier Ltd",
address="Radarweg 29, 1043 NX Amsterdam, The Netherlands",
issn="2352-5738"
}