Detail publikace
Measurement of orientation of fibres in a simplified replica of human trachea under steady conditions
LÍZAL, F. CABALKA, M. MALÝ, M. FARKAS, Á. BĚLKA, M. ŠTARHA, P. JEDELSKÝ, J. JÍCHA, M.
Anglický název
Measurement of orientation of fibres in a simplified replica of human trachea under steady conditions
Typ
konferenční sborník (ne článek)
Jazyk
en
Originální abstrakt
Although inhalable fibres are mostly regarded as dangerous and harmful because they are mostly associated with asbestos, several authors have recommended the application of tubular or fibrous particles for drug delivery. Chan and Gonda (1989) were among the first who ventured to enter the unexplored realm of pharmaceutically usable fibres. They prepared fibres from cromoglycic acid which has low solubility in water and therefore should not experience significant hygroscopic growth in the airways. Johnson et al. (2000) suggested packing tubular shell particles with an Active Pharmaceutical Ingredient (API) to maximise the per particle dose while targeting distal regions of lungs. Martin and Finlay (2008) have demonstrated the applicability of magnetic field targeting of magnetite-loaded fibres for efficient delivery to specified locations in lungs and encouraged other researchers to develop formulations with fibrous aerosol incorporating chemotherapeutic agents for the treatment of lung cancer.
Anglický abstrakt
Although inhalable fibres are mostly regarded as dangerous and harmful because they are mostly associated with asbestos, several authors have recommended the application of tubular or fibrous particles for drug delivery. Chan and Gonda (1989) were among the first who ventured to enter the unexplored realm of pharmaceutically usable fibres. They prepared fibres from cromoglycic acid which has low solubility in water and therefore should not experience significant hygroscopic growth in the airways. Johnson et al. (2000) suggested packing tubular shell particles with an Active Pharmaceutical Ingredient (API) to maximise the per particle dose while targeting distal regions of lungs. Martin and Finlay (2008) have demonstrated the applicability of magnetic field targeting of magnetite-loaded fibres for efficient delivery to specified locations in lungs and encouraged other researchers to develop formulations with fibrous aerosol incorporating chemotherapeutic agents for the treatment of lung cancer.
Klíčová slova anglicky
fibre, fiber, human trachea, human airways, human lungs, measurement
Vydáno
30.10.2019
Nakladatel
Czech Aerosol Society
Místo
Velké Bílovice
ISBN
978-80-270-6416-8
Kniha
PROCEEDINGS OF 20TH ANNUAL CONFERENCE OF THE CZECH AEROSOL SOCIETY
Počet stran
2
BIBTEX
@proceedings{BUT161044,
author="František {Lízal} and Matouš {Cabalka} and Milan {Malý} and Árpád {Farkas} and Miloslav {Bělka} and Pavel {Štarha} and Jan {Jedelský} and Miroslav {Jícha},
title="Measurement of orientation of fibres in a simplified replica of human trachea under steady conditions ",
booktitle="PROCEEDINGS OF 20TH ANNUAL CONFERENCE OF THE CZECH AEROSOL SOCIETY",
year="2019",
month="October",
publisher="Czech Aerosol Society",
address="Velké Bílovice",
isbn="978-80-270-6416-8"
}