Raman spectroscopic analysis of the biochemical reaction of hyaluronic acid in joint replacement

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Hyaluronic acid is a nonprotein component of synovial fluid, which acts as a key reactant in the tribo-chemical mechanics of joint lubrication. In this study, the biochemical responses of hyaluronic acid were evaluated in an artificial hip joint. The experiments are conducted in the ball-on-cup configuration in a hip joint simulator, where the balls are made from respectively cobalt chromium molybdenum alloy and ceramics (biolox forte and biolox delta). The cups are or respectively polyethylene and ceramic. Raman spectroscopic method was used to analyze the biochemical responses. The results revealed that biolox delta ball are could be involved in the chemical reaction with hyaluronic acid as it provides different spectra compare to others. Therefore, the results have significant information regarding hyaluronic acid reactivity within the joint replacement.

Hyaluronic acid is a nonprotein component of synovial fluid, which acts as a key reactant in the tribo-chemical mechanics of joint lubrication. In this study, the biochemical responses of hyaluronic acid were evaluated in an artificial hip joint. The experiments are conducted in the ball-on-cup configuration in a hip joint simulator, where the balls are made from respectively cobalt chromium molybdenum alloy and ceramics (biolox forte and biolox delta). The cups are or respectively polyethylene and ceramic. Raman spectroscopic method was used to analyze the biochemical responses. The results revealed that biolox delta ball are could be involved in the chemical reaction with hyaluronic acid as it provides different spectra compare to others. Therefore, the results have significant information regarding hyaluronic acid reactivity within the joint replacement.

hyaluronic acid, tribology, hip joint replacement,

19.05.2019

Nashville

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