Detail publikace
DNA analyser, a new powerful tool to identify and analyse local DNA structures in genomes
BRÁZDA, V. JAGELSKÁ, E. B. KOLOMAZNÍK, J. LÝSEK, J. KAURA, P. BARTAS, M. COUFAL, J. ŠŤASTNÝ, J.
Anglický název
DNA analyser, a new powerful tool to identify and analyse local DNA structures in genomes
Typ
abstrakt
Jazyk
en
Originální abstrakt
Local DNA structures play important roles in the regulation of basic biological processes. Whilst computational approaches to identify these structures are available, the number of easily accessible and userfriendly tools is limited, especially for analysis of different types of local structures within long nucleotide sequences. We have developed a webbased server, DNA analyser, which is a userfriendly application for analysing local DNA structures. At first we implemented a tool for analyses of inverted repeats in various nucleic acids sequences including genome sequences and oligonucleotides. It allows users to search and retrieve desired gene/nucleotide sequence entries from the NCBI databases, and provides data on length, sequence, locations and energy required for cruciform formation. We have recently included new tools for analyses of quadruplexforming sequences – an interactive webversion of the G4hunter algorithm as well as a tool to search for p53 target sequences. DNA analyser also features an interactive graphical representation of the distribution of local DNA structures and options for sorting and data export. DNA analyser allows whole genome analyses and it is freely available at http://bioinformatics.ibp.cz
Anglický abstrakt
Local DNA structures play important roles in the regulation of basic biological processes. Whilst computational approaches to identify these structures are available, the number of easily accessible and userfriendly tools is limited, especially for analysis of different types of local structures within long nucleotide sequences. We have developed a webbased server, DNA analyser, which is a userfriendly application for analysing local DNA structures. At first we implemented a tool for analyses of inverted repeats in various nucleic acids sequences including genome sequences and oligonucleotides. It allows users to search and retrieve desired gene/nucleotide sequence entries from the NCBI databases, and provides data on length, sequence, locations and energy required for cruciform formation. We have recently included new tools for analyses of quadruplexforming sequences – an interactive webversion of the G4hunter algorithm as well as a tool to search for p53 target sequences. DNA analyser also features an interactive graphical representation of the distribution of local DNA structures and options for sorting and data export. DNA analyser allows whole genome analyses and it is freely available at http://bioinformatics.ibp.cz
Klíčová slova anglicky
DNA analyser, DNA structures, G4hunter algorithm
Vydáno
06.07.2019
ISSN
2211-5463
Ročník
9
Číslo
S1
Strany od–do
149–149
Počet stran
1