Detail publikace
Bendo-tensegrity model simulates compression test of animal cell
BANSOD, Y. JAKKA, V. BURŠA, J.
Anglický název
Bendo-tensegrity model simulates compression test of animal cell
Typ
článek ve sborníku ve WoS nebo Scopus
Jazyk
en
Originální abstrakt
A hybrid model of suspended animal cell proposed earlier, with a bendo-tensegrity structure mimicking cytoskeleton, is applied to simulate the global response of the cell under compression and to describe mechanical behaviour of its components. The Finite Element model incorporates Microtubules, Actin Filaments, Intermediate Filaments, nucleus, cytoplasm, and Cell Membrane, all of them with realistic geometrical and material parameters. The unique features of this structural model keep fundamental principles governing cell behaviour, such as interaction between the cytoskeletal components redistributing the prestress of actin filaments throughout all the structure. The force-deformation curve from the simulated compression test with microplates is validated by comparison with the experimental response from literature. The model enables us to investigate the mechanical role of individual celular and cytoskeletal components in intracellular force propagation by means of changing their numbers or parameters. As quantitative characterization of nucleus deformation may be hypothetically decisive for mechanotransduction, the model aims at better understanding of how cellular processes are mechanically controlled.
Anglický abstrakt
A hybrid model of suspended animal cell proposed earlier, with a bendo-tensegrity structure mimicking cytoskeleton, is applied to simulate the global response of the cell under compression and to describe mechanical behaviour of its components. The Finite Element model incorporates Microtubules, Actin Filaments, Intermediate Filaments, nucleus, cytoplasm, and Cell Membrane, all of them with realistic geometrical and material parameters. The unique features of this structural model keep fundamental principles governing cell behaviour, such as interaction between the cytoskeletal components redistributing the prestress of actin filaments throughout all the structure. The force-deformation curve from the simulated compression test with microplates is validated by comparison with the experimental response from literature. The model enables us to investigate the mechanical role of individual celular and cytoskeletal components in intracellular force propagation by means of changing their numbers or parameters. As quantitative characterization of nucleus deformation may be hypothetically decisive for mechanotransduction, the model aims at better understanding of how cellular processes are mechanically controlled.
Klíčová slova anglicky
cell mechanics, cytoskeleton, bendo-tensegrity model, compression test simulation
Vydáno
14.05.2018
ISBN
978-80-86246-88-8
Kniha
Engineering Mechanics 2018
Strany od–do
45–48
Počet stran
4
BIBTEX
@inproceedings{BUT151655,
author="Yogesh Deepak {Bansod} and Veera Venkata Satya {Jakka} and Jiří {Burša},
title="Bendo-tensegrity model simulates compression test of animal cell",
booktitle="Engineering Mechanics 2018",
year="2018",
month="May",
pages="45--48",
isbn="978-80-86246-88-8"
}