Detail publikace
Palindrome analyser – A new web-based server for predicting and evaluating inverted repeats in nucleotide sequences
BRÁZDA, V. KOLOMAZNÍK, J. LÝSEK, J. HÁRONÍKOVÁ, L. COUFAL, J. ŠŤASTNÝ, J.
Anglický název
Palindrome analyser – A new web-based server for predicting and evaluating inverted repeats in nucleotide sequences
Typ
článek v časopise ve Web of Science, Jimp
Jazyk
en
Originální abstrakt
DNA cruciform structures play an important role in the regulation of natural processes including gene replication and expression, as well as nucleosome structure and recombination. They have also been implicated in the evolution and development of diseases such as cancer and neurodegenerative disorders. Cruciform structures are formed by inverted repeats, and their stability is enhanced by DNA supercoiling and protein binding. They have received broad attention because of their important roles in biology. Computational approaches to study inverted repeats have allowed detailed analysis of genomes. However, currently there are no easily accessible and user-friendly tools that can analyse inverted repeats, especially among long nucleotide sequences. We have developed a web-based server, Palindrome analyser, which is a user-friendly application for analysing inverted repeats in various DNA (or RNA) sequences including genome sequences and oligonucleotides. It allows users to search and retrieve desired gene/nucleotide sequence entries from the NCBI databases, and provides data on length, sequence, locations and energy required for cruciform formation.
Anglický abstrakt
DNA cruciform structures play an important role in the regulation of natural processes including gene replication and expression, as well as nucleosome structure and recombination. They have also been implicated in the evolution and development of diseases such as cancer and neurodegenerative disorders. Cruciform structures are formed by inverted repeats, and their stability is enhanced by DNA supercoiling and protein binding. They have received broad attention because of their important roles in biology. Computational approaches to study inverted repeats have allowed detailed analysis of genomes. However, currently there are no easily accessible and user-friendly tools that can analyse inverted repeats, especially among long nucleotide sequences. We have developed a web-based server, Palindrome analyser, which is a user-friendly application for analysing inverted repeats in various DNA (or RNA) sequences including genome sequences and oligonucleotides. It allows users to search and retrieve desired gene/nucleotide sequence entries from the NCBI databases, and provides data on length, sequence, locations and energy required for cruciform formation.
Klíčová slova anglicky
Palindrome analyser, web-based server, inverted repeats, nucleotide sequences, DNA sequences
Vydáno
30.09.2016
ISSN
0006-291X
Ročník
479
Číslo
2
Strany od–do
1739–1745
Počet stran
7
BIBTEX
@article{BUT128435,
author="Václav {Brázda} and Jan {Kolomazník} and Jiří {Lýsek} and Jan {Coufal} and Jiří {Šťastný},
title="Palindrome analyser – A new web-based server for predicting and evaluating inverted repeats in nucleotide sequences",
year="2016",
volume="479",
number="2",
month="September",
pages="1739--1745",
issn="0006-291X"
}