Detail publikace
Výzkum transportu a depozice aerosolu v modelu lidkých dýchacích cest
LÍZAL, F. JEDELSKÝ, J. ELCNER, J. ĎURDINA, L. HALASOVÁ, T. MRAVEC, F. JÍCHA, M.
Český název
Výzkum transportu a depozice aerosolu v modelu lidkých dýchacích cest
Anglický název
Research of transport and deposition of aerosol in human airway replica
Typ
článek ve sborníku ve WoS nebo Scopus
Jazyk
en
Originální abstrakt
Growing concern about knowledge of aerosol transport in human lungs is caused by great potential of use of inhaled pharmaceuticals. Second substantial motive for the research is an effort to minimize adverse effects of particular matter emitted by traffic and industry on human health. We created model geometry of human lungs to 7th generation of branching. This model geometry was used for fabrication of two physical models. The first one is made from thin walled transparent silicone and it allows a measurement of velocity and size of aerosol particles by Phase Doppler Anemometry (PDA). The second one is fabricated by stereolithographic method and it is designed for aerosol deposition measurements. We provided a series of measurements of aerosol transport in the transparent model and we ascertained remarkable phenomena linked with lung flow. The results are presented in brief. To gather how this phenomena affects aerosol deposition in human lungs we used the second model and we developed a technique for deposition fraction and deposition efficiency assessment. The results confirmed that non-symmetric and complicated shape of human airways essentially affects transport and deposition of aerosol. The research will now focus on deeper insight in aerosol deposition.
Český abstrakt
Rostoucí zájem o znalost transportu aerosolu v lidských plicích je zapříčiněn velkým potenciálem užití inhalovaných farmaceutik. Druhým podstatným motivem výzkumu je snaha minimalizovat škodlivé účinky aerosolů emitovaných průmyslem a dopravou. Vytvořili jsme modelovou geometrii plic do 7. generace, z níž vznikly dva modely. První je opticky transparentní a umožňuje studium transportu aerosolu pomocí optických měřicích metod, druhý je segmentový a umožňuje měření lokální depozice aerosolu. V článku jsou v krátkosti prezentovány první výsledky.
Anglický abstrakt
Growing concern about knowledge of aerosol transport in human lungs is caused by great potential of use of inhaled pharmaceuticals. Second substantial motive for the research is an effort to minimize adverse effects of particular matter emitted by traffic and industry on human health. We created model geometry of human lungs to 7th generation of branching. This model geometry was used for fabrication of two physical models. The first one is made from thin walled transparent silicone and it allows a measurement of velocity and size of aerosol particles by Phase Doppler Anemometry (PDA). The second one is fabricated by stereolithographic method and it is designed for aerosol deposition measurements. We provided a series of measurements of aerosol transport in the transparent model and we ascertained remarkable phenomena linked with lung flow. The results are presented in brief. To gather how this phenomena affects aerosol deposition in human lungs we used the second model and we developed a technique for deposition fraction and deposition efficiency assessment. The results confirmed that non-symmetric and complicated shape of human airways essentially affects transport and deposition of aerosol. The research will now focus on deeper insight in aerosol deposition.
Klíčová slova česky
model plic, model lidských plic, depozice aerosolu, transport aerosolu, usazování aerosolu
Klíčová slova anglicky
human lung model, aerosol deposition, lung replica, airway model, airway replica, aerosol transport
Rok RIV
2010
Vydáno
24.11.2010
Nakladatel
EDP Sciences
Místo
Francie
ISBN
978-80-7372-670-6
ISSN
2100-014X
Kniha
EPJ Web of Conferences
Ročník
25
Číslo
1
Strany od–do
1–12
Počet stran
12
BIBTEX
@inproceedings{BUT34747,
author="František {Lízal} and Jan {Jedelský} and Jakub {Elcner} and Lukáš {Ďurdina} and Tereza {Venerová} and Filip {Mravec} and Miroslav {Jícha},
title="Research of transport and deposition of aerosol in human airway replica",
booktitle="EPJ Web of Conferences",
year="2010",
volume="25",
number="1",
month="November",
pages="1--12",
publisher="EDP Sciences",
address="Francie",
isbn="978-80-7372-670-6",
issn="2100-014X"
}