Publication detail
Research of transport and deposition of aerosol in human airway replica
LÍZAL, F. JEDELSKÝ, J. ELCNER, J. ĎURDINA, L. HALASOVÁ, T. MRAVEC, F. JÍCHA, M.
Czech title
Výzkum transportu a depozice aerosolu v modelu lidkých dýchacích cest
English title
Research of transport and deposition of aerosol in human airway replica
Type
conference paper
Language
en
Original abstract
Growing concern about knowledge of aerosol transport in human lungs is caused by great potential of use of inhaled pharmaceuticals. Second substantial motive for the research is an effort to minimize adverse effects of particular matter emitted by traffic and industry on human health. We created model geometry of human lungs to 7th generation of branching. This model geometry was used for fabrication of two physical models. The first one is made from thin walled transparent silicone and it allows a measurement of velocity and size of aerosol particles by Phase Doppler Anemometry (PDA). The second one is fabricated by stereolithographic method and it is designed for aerosol deposition measurements. We provided a series of measurements of aerosol transport in the transparent model and we ascertained remarkable phenomena linked with lung flow. The results are presented in brief. To gather how this phenomena affects aerosol deposition in human lungs we used the second model and we developed a technique for deposition fraction and deposition efficiency assessment. The results confirmed that non-symmetric and complicated shape of human airways essentially affects transport and deposition of aerosol. The research will now focus on deeper insight in aerosol deposition.
Czech abstract
Rostoucí zájem o znalost transportu aerosolu v lidských plicích je zapříčiněn velkým potenciálem užití inhalovaných farmaceutik. Druhým podstatným motivem výzkumu je snaha minimalizovat škodlivé účinky aerosolů emitovaných průmyslem a dopravou. Vytvořili jsme modelovou geometrii plic do 7. generace, z níž vznikly dva modely. První je opticky transparentní a umožňuje studium transportu aerosolu pomocí optických měřicích metod, druhý je segmentový a umožňuje měření lokální depozice aerosolu. V článku jsou v krátkosti prezentovány první výsledky.
English abstract
Growing concern about knowledge of aerosol transport in human lungs is caused by great potential of use of inhaled pharmaceuticals. Second substantial motive for the research is an effort to minimize adverse effects of particular matter emitted by traffic and industry on human health. We created model geometry of human lungs to 7th generation of branching. This model geometry was used for fabrication of two physical models. The first one is made from thin walled transparent silicone and it allows a measurement of velocity and size of aerosol particles by Phase Doppler Anemometry (PDA). The second one is fabricated by stereolithographic method and it is designed for aerosol deposition measurements. We provided a series of measurements of aerosol transport in the transparent model and we ascertained remarkable phenomena linked with lung flow. The results are presented in brief. To gather how this phenomena affects aerosol deposition in human lungs we used the second model and we developed a technique for deposition fraction and deposition efficiency assessment. The results confirmed that non-symmetric and complicated shape of human airways essentially affects transport and deposition of aerosol. The research will now focus on deeper insight in aerosol deposition.
Keywords in Czech
model plic, model lidských plic, depozice aerosolu, transport aerosolu, usazování aerosolu
Keywords in English
human lung model, aerosol deposition, lung replica, airway model, airway replica, aerosol transport
RIV year
2010
Released
24.11.2010
Publisher
EDP Sciences
Location
Francie
ISBN
978-80-7372-670-6
ISSN
2100-014X
Book
EPJ Web of Conferences
Volume
25
Number
1
Pages from–to
1–12
Pages count
12
BIBTEX
@inproceedings{BUT34747,
author="František {Lízal} and Jan {Jedelský} and Jakub {Elcner} and Lukáš {Ďurdina} and Tereza {Venerová} and Filip {Mravec} and Miroslav {Jícha},
title="Research of transport and deposition of aerosol in human airway replica",
booktitle="EPJ Web of Conferences",
year="2010",
volume="25",
number="1",
month="November",
pages="1--12",
publisher="EDP Sciences",
address="Francie",
isbn="978-80-7372-670-6",
issn="2100-014X"
}